Br J Haematol. 2008 Apr;141(1):32-5.

Ehlers-Danlos syndrome--a historical review.

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Haemophilia Centre, Bradford Teaching Hospitals Foundation Trust, Bradford Royal Infirmary, Duckworth Lane, Bradford BD9 6RJ, UK. parapia@doctors.org.uk

Abstract

Ehlers-Danlos syndrome is an inherited heterogeneous group of connective tissue disorders, characterized by abnormal collagen synthesis, affecting skin, ligaments, joints, blood vessels and other organs. It is one of the oldest known causes of bruising and bleeding and was first described by Hipprocrates in 400 BC. Edvard Ehlers, in 1901, recognized the condition as a distinct entity. In 1908, Henri-Alexandre Danlos suggested that skin extensibility and fragility were the cardinal features of the syndrome. In 1998, Beighton published the classification of Ehlers-Danlos syndrome according to the Villefranche nosology. From the 1960s the genetic make up was identified. Management of bleeding problems associated with Ehlers-Danlos has been slow to progress.

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Ehlers-Danlos syndromes: revised nosology, Villefranche, 1997. Ehlers-Danlos National Foundation (USA) and Ehlers-Danlos Support Group (UK). [Am J Med Genet. 1998]
Ehlers-Danlos syndromes: revised nosology, Villefranche, 1997. Ehlers-Danlos National Foundation (USA) and Ehlers-Danlos Support Group (UK).
Beighton P, De Paepe A, Steinmann B, Tsipouras P, Wenstrup RJ. Am J Med Genet. 1998 Apr 28; 77(1):31-7.
Review [Ehlers-Danlos syndrome--diagnosis and subclassification]. [Tidsskr Nor Laegeforen. 2006]
Review [Ehlers-Danlos syndrome--diagnosis and subclassification].
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The Ehlers-Danlos syndrome: recognition, characterization, and importance of a milder variant of the classic form. A preliminary study.
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[Joint hypermobility, skin hyper-elasticity, connective tissue fragility: classical symptoms of Ehlers-Danlos syndrome]. [Lakartidningen. 1995]
[Joint hypermobility, skin hyper-elasticity, connective tissue fragility: classical symptoms of Ehlers-Danlos syndrome].
Häggblom L, Sanner G. Lakartidningen. 1995 Dec 13; 92(50):4809-13.

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Cited by 6 PubMed Central articles

Ehlers-Danlos syndrome associated with cleft lip and palate. [Can J Plast Surg. 2009]
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Tan PW, Song C, Lalonde D. Can J Plast Surg. 2009 Winter; 17(4):e24-6.
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Im JS, Lim YH, Park JS, Lee SS, Kim KM. Korean J Anesthesiol. 2010 Jun; 58(6):555-9. Epub 2010 Jun 23.
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