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Expert Opin Drug Saf. 2008 Mar;7(2):195-209. doi: 10.1517/14740338.7.2.195 .

Antiepileptic drugs as human teratogens.

Author information

  • University of Queensland, and Royal Brisbane and Women's Hospital, Herston, Brisbane, Australia 4029, Australia. M.Eadie@uq.edu.au

Abstract

BACKGROUND:

There is still uncertainty concerning the risk of fetal malformation associated with the intake of various individual antiepileptic drugs in pregnant women.

OBJECTIVE:

To assess the better-quality available evidence concerning the fetal hazards from exposure to antiepileptic drug monotherapy during human pregnancy.

METHOD:

Examination of the available English language literature, particularly that dealing with individual antiepileptic drugs used in monotherapy, in the larger case series with better-quality internal comparison data.

CONCLUSIONS:

There is reasonable evidence that valproate is a significant teratogen during therapeutic use in women; the other older antiepileptic drugs (phenobarbitone, phenytoin, carbamazepine) probably have some teratogenic potential, but less than valproate; the situation regarding the more recently marketed antiepileptic drugs is not yet clear.

PMID:
18324882
[PubMed - indexed for MEDLINE]
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