Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
World J Gastroenterol. 2008 Mar 7;14(9):1389-93.

Liver histology in ICU patients dying from sepsis: a clinico-pathological study.

Author information

  • 12nd Department of Internal Medicine, Athens Medical School, and Intensive Care Unit, Hippocration General Hospital, 114 Vas. Sofias Ave, Athens 11527, Greece. labsures@med.uoa.gr

Abstract

AIM:

To determine end-stage pathologic changes in the liver of septic patients dying in the intensive care unit.

METHODS:

Needle liver biopsies obtained immediately after death from 15 consecutive patients with sepsis and no underlying liver disease were subjected to routine histological examination. Liver function tests and clinical monitoring measurements were also recorded.

RESULTS:

Liver biochemistries were increased in the majority of patients before death. Histology of liver biopsy specimens showed portal inflammation in 73.3%, centrilobular necrosis in 80%, lobular inflammation in 66.7%, hepatocellular apoptosis in 66.6% and cholangitis/cholangiolitis in 20% of patients. Mixed hepatitic/cholestatic type of liver injury was observed in 6/15 (40%) patients and hepatitc in 9/15 (60%). Steatosis was observed in 11/15 (73.3%) patients affecting 5%-80% of liver parenchyma. Among the histological features, the presence of portal inflammation in liver biopsy was associated with increased hospitalization in the ICU prior death (P=0.026).

CONCLUSION:

Features of hepatitis and steatosis are the main histological findings in the liver in the majority of patients dying from sepsis.

PMID:
18322953
[PubMed - indexed for MEDLINE]
PMCID:
PMC2693687
Free PMC Article

Images from this publication.See all images (1)Free text

Figure 1
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Baishideng Publishing Group Inc. Icon for PubMed Central
    Loading ...
    Write to the Help Desk