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Nat Rev Mol Cell Biol. 2008 Apr;9(4):309-22. doi: 10.1038/nrm2369. Epub 2008 Mar 5.

Tracking the ends: a dynamic protein network controls the fate of microtubule tips.

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  • 1Department of Cell Biology, Erasmus Medical Center, P.O. Box 2040, 3000 CA Rotterdam, the Netherlands.


Microtubule plus-end tracking proteins (+TIPs) are a diverse group of evolutionarily conserved cellular factors that accumulate at the ends of growing microtubules. They form dynamic networks through the interaction of a limited set of protein modules, repeat sequences and linear motifs that bind to each other with moderate affinities. +TIPs regulate different aspects of cell architecture by controlling microtubule dynamics, microtubule interactions with cellular structures and signalling factors, and the forces that are exerted on microtubule networks.

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