Onkologie. 2008 Mar;31(3):119-21. Epub 2008 Feb 8.

Complete response of CNS-involved olfactory neuroendocrine tumor using multimodal therapy.

Ahuja G, Cuellar S, Choudhry I, Setty S, Yao M, Villano JL.

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Department of Medicine, The University of Illinois at Chicago, IL 60612, USA.

Abstract

INTRODUCTION:

Locally advanced tumors in the olfactory area commonly have central nervous system (CNS) involvement and are often incurable.

CASE REPORT:

We report the treatment of a 25-year-old male patient who presented with a large, neuroendocrine tumor arising from the ethmoid complex. This locally invasive lesion extended beyond the orbits and into the anterior cranial fossa with associated intracranial involvement. An endoscopic nasal biopsy demonstrated a poorly differentiated neuroendocrine tumor. The patient was treated with 4 cycles of combination induction chemotherapy with irinotecan and cisplatin followed by radiation therapy with concurrent weekly cisplatin. He had a complete response to this therapy confirmed with biopsies that demonstrated no residual disease at 8 weeks after chemoradiotherapy. He remained disease free one and a half years following surgery.

CONCLUSION:

To our knowledge, this combination treatment approach has not been reported in the literature.

PMID:: 18322415; [PubMed - indexed for MEDLINE]

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