Clinical characteristics associated with isolation of small-colony variants of Staphylococcus aureus and Pseudomonas aeruginosa from respiratory secretions of patients with cystic fibrosis

Michael Schneider; Kathrin Mühlemann; Sara Droz; Sabine Couzinet; Carmen Casaulta; Stefan Zimmerli

doi:10.1128/JCM.00361-08

Clinical characteristics associated with isolation of small-colony variants of Staphylococcus aureus and Pseudomonas aeruginosa from respiratory secretions of patients with cystic fibrosis

J Clin Microbiol. 2008 May;46(5):1832-4. doi: 10.1128/JCM.00361-08. Epub 2008 Mar 5.

Authors

Michael Schneider¹, Kathrin Mühlemann, Sara Droz, Sabine Couzinet, Carmen Casaulta, Stefan Zimmerli

Affiliation

¹ Institute for Infectious Diseases, University of Bern, Friedbuehlstr. 51, P.O. Box 61, CH-3010 Bern, Switzerland.

Abstract

During a 3-month period, small-colony variant phenotypes of both Staphylococcus aureus and Pseudomonas aeruginosa were isolated from respiratory secretions of 8.2% and 9.2%, respectively, of 98 patients with cystic fibrosis, particularly those with advanced pulmonary disease and prolonged antibiotic exposure.

MeSH terms

Adolescent
Adult
Anti-Bacterial Agents / therapeutic use
Carrier State / microbiology
Child
Child, Preschool
Cystic Fibrosis / complications*
Humans
Infant
Pseudomonas Infections / microbiology*
Pseudomonas Infections / pathology
Pseudomonas Infections / physiopathology
Pseudomonas aeruginosa / growth & development*
Pseudomonas aeruginosa / isolation & purification
Respiratory System / metabolism
Respiratory System / microbiology
Staphylococcal Infections / microbiology*
Staphylococcal Infections / pathology
Staphylococcal Infections / physiopathology
Staphylococcus aureus / growth & development*
Staphylococcus aureus / isolation & purification

Substances

Anti-Bacterial Agents