Design, synthesis and antiproliferative properties of oligomers with chromophore units linked by amide backbones.
Farrera-Sinfreu J,
Aviñó A,
Navarro I,
Aymamí J,
Beteta NG,
Varón S,
Pérez-Tomás R,
Castillo-Avila W,
Eritja R,
Albericio F,
Royo M.
Combinatorial Chemistry Unit, Barcelona Scientific Park (PCB), Josep Samitier 1-5, E-08028 Barcelona, Spain.
The preparation of oligomers made up of several chromophore units as compounds with potential fluorescent and antiproliferative properties is described. Specifically, chromophore units with protected-amino groups and one carboxylic group are described, together with methods to assemble these units using peptide chemistry. Some of these compounds have antiproliferative activity.
PMID: 18321705 [PubMed - indexed for MEDLINE]