Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Theor Popul Biol. 2008 May;73(3):342-8. doi: 10.1016/j.tpb.2008.01.001. Epub 2008 Jan 30.

Can one learn history from the allelic spectrum?

Author information

  • 1Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge MA 02142, United States.

Abstract

It is well known that the neutral allelic frequency spectrum of a population is affected by the history of population size. A number of authors have used this fact to infer history given observed allele frequency data. We ask whether perfect information concerning the spectrum allows precise recovery of the history, and with an explicit example show that the answer is in the negative. This implies some limitations on how informative allelic spectra can be.

PMID:
18321552
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk