Nat Clin Pract Rheumatol. 2008 Apr;4(4):210-7. Epub 2008 Mar 4.

Primer: SNP-associated studies and what they can teach us.

Source

Laboratory of Functional Genomics at the Human Genome Center, Institute of Medical Science, University of Tokyo, Japan. ryamada@src.riken.go.jp

Abstract

Single-nucleotide polymorphisms (SNPs) are single base-pair alterations in the DNA sequence that represent a major source of genetic heterogeneity. Well-developed and sophisticated technologies exist to measure and analyze the presence of SNPs, and SNP genotyping is an important tool with which to investigate other genetic variants. SNP-based, large-scale, genome-wide association studies are detecting many polymorphisms that can be used to evaluate the risk of various common traits, including rheumatic diseases. This increased knowledge of genetic risk could potentially be used to refine medical care in rheumatology clinics in the near future.

PMID:: 18319711; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

Genetic Markers

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Save items

Related citations in PubMed

SNPs in Multi-species Conserved Sequences (MCS) as useful markers in association studies: a practical approach. [BMC Genomics. 2007]
SNPs in Multi-species Conserved Sequences (MCS) as useful markers in association studies: a practical approach.
McCauley JL, Kenealy SJ, Margulies EH, Schnetz-Boutaud N, Gregory SG, Hauser SL, Oksenberg JR, Pericak-Vance MA, Haines JL, Mortlock DP. BMC Genomics. 2007 Aug 6; 8:266. Epub 2007 Aug 6.
Common deletions and SNPs are in linkage disequilibrium in the human genome. [Nat Genet. 2006]
Common deletions and SNPs are in linkage disequilibrium in the human genome.
Hinds DA, Kloek AP, Jen M, Chen X, Frazer KA. Nat Genet. 2006 Jan; 38(1):82-5. Epub 2005 Dec 4.
Single-nucleotide polymorphism genotyping for disease association studies. [Methods Mol Med. 2005]
Single-nucleotide polymorphism genotyping for disease association studies.
Fornage M, Doris PA. Methods Mol Med. 2005; 108:159-72.
Review High-throughput SNP analysis for genetic association studies. [Curr Opin Drug Discov Devel. 2...]
Review High-throughput SNP analysis for genetic association studies.
Marnellos G. Curr Opin Drug Discov Devel. 2003 May; 6(3):317-21.
Review Applications of whole-genome high-density SNP genotyping. [Expert Rev Mol Diagn. 2005]
Review Applications of whole-genome high-density SNP genotyping.
Craig DW, Stephan DA. Expert Rev Mol Diagn. 2005 Mar; 5(2):159-70.

See reviews... See all...

Cited by 1 PubMed Central article

Evidence of uneven selective pressure on different subsets of the conserved human genome; implications for the significance of intronic and intergenic DNA. [BMC Genomics. 2009]
Evidence of uneven selective pressure on different subsets of the conserved human genome; implications for the significance of intronic and intergenic DNA.
Davidson S, Starkey A, MacKenzie A. BMC Genomics. 2009 Dec 16; 10:614. Epub 2009 Dec 16.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Primer: SNP-associated studies and what they can teach us.
Primer: SNP-associated studies and what they can teach us.
Nat Clin Pract Rheumatol. 2008 Apr ;4(4):210-7. Epub 2008 Mar 4 .

PubMed
Eating on the fly: function and regulation of autophagy during cell growth, surv...
Eating on the fly: function and regulation of autophagy during cell growth, survival and death in Drosophila.
Autophagy. 2008 Jul ;4(5):557-62. Epub 2008 Feb 23 .

PubMed
Trisomy 21: association between reduced recombination and nondisjunction.
Trisomy 21: association between reduced recombination and nondisjunction.
Am J Hum Genet. 1991 Sep ;49(3):608-20.

PubMed
Prospective study of the association between fluoride intake and dental fluorosi...
Prospective study of the association between fluoride intake and dental fluorosis in permanent teeth.
Caries Res. 2008 ;42(2):125-33. Epub 2008 Mar 4 .

PubMed
High sensitivity C-reactive protein and immunoglobulin G against Chlamydia pneum...
High sensitivity C-reactive protein and immunoglobulin G against Chlamydia pneumoniae and chlamydial heat shock protein-60 in ischemic heart disease.
Iran J Immunol. 2008 Mar ;5(1):51-6.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: