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Expert Opin Drug Deliv. 2008 Mar;5(3):353-69. doi: 10.1517/17425247.5.3.353 .

Thermally targeted delivery of chemotherapeutics and anti-cancer peptides by elastin-like polypeptide.

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  • 1University of Mississippi Medical Center, Department of Biochemistry, 2500 North State Street, Jackson, MS 39216, USA. draucher@biochem.umsmed.edu

Abstract

Current chemotherapy treatment of solid tumors is limited due to a lack of specific delivery of the drugs to the tumor, leading to systemic toxicity. Therefore, it is necessary to develop targeted cancer therapies and tumor-targeted drug carriers. The authors review the development of elastin-like polypeptide (ELP) as a potential carrier for thermally targeted delivery of therapeutics. The authors searched Medline for articles concerning the application of ELP as a drug delivery vector for small molecule drugs and therapeutic peptides. ELP has been demonstrated to be a promising thermally targeted carrier. Further examination of the in vivo biodistribution and efficacy will provide the necessary data to advance ELP technology toward the ultimate goal of human therapeutics.

PMID:
18318656
[PubMed - indexed for MEDLINE]
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