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1: Int J Gynecol Pathol. 2008 Apr;27(2):223-8. Links

Krukenberg tumor with yolk sac tumor differentiation.

Zamecnik M, Voltr L, Stuk J, Chlumska A.

Sikl's Department of Pathology, Charles University. zamecnik@medima.cz

An unusual case of bilateral Krukenberg tumor with foci of yolk sac tumor (YST) differentiation occurring in a 50-year-old patient is reported. The primary tumor was in the gastric antrum, and it showed morphology of poorly differentiated adenocarcinoma with diffuse and solid growth pattern. A component of typical YST was not found in the gastric primary and lymph node metastases, although some cells in these locations were positive for alpha-fetoprotein. In the ovarian metastases, YST element showed microcystic/reticular and solid patterns, whereas the adenocarcinoma component was of diffuse type with signet ring cells and with some undifferentiated areas. The case represents further example of the somatic cell-derived tumor with focal germ cell-type differentiation and the first report of YST differentiation in Krukenberg tumor.

PMID: 18317220 [PubMed - indexed for MEDLINE]