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Cell Metab. 2008 Mar;7(3):200-3. doi: 10.1016/j.cmet.2008.01.001.

Stress-response hormesis and aging: "that which does not kill us makes us stronger".

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  • 1Institute of Healthy Ageing and Department of Genetics, Environment and Evolution, University College London, London WC1E 6BT, UK.


Hormesis refers to the beneficial effects of a treatment that at a higher intensity is harmful. In one form of hormesis, sublethal exposure to stressors induces a response that results in stress resistance. The principle of stress-response hormesis is increasingly finding application in studies of aging, where hormetic increases in life span have been seen in several animal models.

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