Ecole Normale Supérieure, CNRS UMR8542, 46 rue d'Ulm, 75005 Paris, France.
The precise role of the O-fucosyltransferase Ofut1 in Notch-receptor trafficking has remained controversial. A recent study sheds new light on the non-catalytic activity of Ofut1 and provides further evidence that Ofut1 acts as a chaperone in the endoplasmic reticulum.