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Br J Psychiatry. 2008 Mar;192(3):161-3. doi: 10.1192/bjp.bp.107.037218.

CATIE and CUtLASS: can we handle the truth?

Abstract

Two large, non-commercial clinical trials comparing first- and second-generation antipsychotic drugs for people with chronic schizophrenia in the US and UK have shown unexpected results. In general, the newer drugs were no more effective or better tolerated than the older drugs. Clozapine outperformed other second-generation drugs. The implications are considered.

PMID:
18310570
[PubMed - indexed for MEDLINE]
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