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    J Perinatol. 2008 Mar;28(3):233-4.

    Daptomycin use in infants: report of two cases with peak and trough drug concentrations.

    Cohen-Wolkowiez M, Smith PB, Benjamin DK Jr, Fowler VG Jr, Wade KC.

    Source

    Department of Pediatrics, Duke University, Durham, NC, USA.

    Abstract

    We report two infants treated with daptomycin for methicillin-resistant Staphylococcus aureus infection and describe peak and trough blood concentrations measured during therapy. The peak concentrations were 41.7 and 36.7 mcg ml(-1), and the 12-hour trough concentrations were 12.7 and 16.3 mcg ml(-1), respectively. Even though the infants received higher doses than adults, their drug concentrations were comparable to those observed in adults treated with regular dosing of daptomycin.

    PMID:
    18309318
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2752140
    Free PMC Article

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