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Endocr Pract. 2008 Mar;14(2):185-91.

Inpatient glycemic control on the vascular surgery service.

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  • 1Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.

Abstract

OBJECTIVE:

To describe a structured inpatient insulin management protocol and order set for glycemic control on a vascular surgery service.

METHODS:

Patients admitted to the vascular surgery service with underlying diabetes were enrolled in a study of use of a preprinted basal-bolus insulin order set based on a total daily dose of 0.5 U/kg (0.25 U/kg of insulin glargine and 0.25 U/kg of insulin as part divided into 3 equal mealtime doses). Outcomes included the mean glycemic control at each of 5 established time intervals, the percentage of blood glucose measurements within the target range of 70 to 180 mg/dL, the incidence of hypoglycemia, and the insulin dosages. Historical control patients with diabetes from the same hospital service were used for comparison.

RESULTS:

Both the study group and the control group consisted of 26 patients. The number of finger-stick blood glucose measurements performed was 871 in the control group and 896 in the intervention group. The mean blood glucose level (+/- SD) for the intervention group was 149.4 +/- 50.7 mg/dL, in comparison with 165.2 +/- 64.4 mg/dL for the control group. The incidence of hypoglycemia decreased 50% in the intervention group-from 32 (4% of the finger-stick assessments in the control group) to 19 (2% of the finger-stick blood glucose measurements in the study group). The blood glucose target range of 70 to 180 mg/dL was achieved in 75% of the measurements in the study group versus 61% in the control group. The basal insulin dose was unchanged in 65% of the patients, and of the 9 patients requiring a change in the dose, 5 had the dose decreased by 10% and 4 had the dose increased by 10%.

CONCLUSION:

The use of a standardized basal-bolus weight-based insulin regimen was successful at achieving improved glycemic control as well as reducing the incidence of hypoglycemia in an inpatient population with diabetes.

PMID:
18308656
[PubMed - indexed for MEDLINE]
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