Send to

Choose Destination
See comment in PubMed Commons below
Neuropharmacology. 2008 Sep;55(3):310-8. doi: 10.1016/j.neuropharm.2008.01.005. Epub 2008 Jan 25.

Mechanisms of ischemic brain damage.

Author information

  • 1Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97239, USA.


In the United States stroke is the third leading cause of death and the leading cause of disability. Brain injury following stroke results from the complex interplay of multiple pathways including excitotoxicity, acidotoxicity, ionic imbalance, peri-infarct depolarization, oxidative and nitrative stress, inflammation and apoptosis. There are very few treatments for stroke and the development of new treatments requires a comprehensive understanding of the diverse mechanisms of ischemic brain damage that are responsible for neuronal death. Here, we discuss the underlying pathophysiology of this devastating disease and reveal the intertwined pathways that are the target of therapeutic intervention.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk