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J Cell Biochem. 2008 Jul 1;104(4):1356-63. doi: 10.1002/jcb.21712.

Novel anti-angiogenic peptides derived from ELR-containing CXC chemokines.

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  • 1Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. ekaragi1@jhmi.edu

Abstract

Angiogenesis is tightly regulated by numerous endogenous pro- and anti-angiogenic proteins and peptides. Among these are the CXC chemokines, a set of multifunctional peptides. CXC chemokines containing the ELR motif act as pro-angiogenic agents by regulating both endothelial cell proliferation and migration. Here we show that a set of six 22-24-amino acid peptides derived from the pro-angiogenic ELR-containing CXC chemokines exhibit notable anti-proliferative and anti-migratory activity in vitro; we call these peptides chemokinostatins. The ability of the identified peptides to inhibit the basic components of angiogenesis even though they are derived from pro-angiogenic proteins contributes towards the understanding of the diverse role of the CXC chemokine family in angiogenesis.

2008 Wiley-Liss, Inc.

PMID:
18307172
[PubMed - indexed for MEDLINE]
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