Chemphyschem. 2008 Mar 14;9(4):641-5.

An acoustically driven microliter flow chamber on a chip (muFCC) for cell-cell and cell-surface interaction studies.

Schneider MF, Guttenberg Z, Schneider SW, Sritharan K, Myles VM, Pamukci U, Wixforth A.

Source

University of Augsburg, Experimental Physics I, Biological Physics Group, Univeristätstr. 1, 86159 Augsburg, Germany. matthias.schneider@physik.uni-augsburg.de

Abstract

A novel method for pumping very small volumes of liquid by using surface acoustic waves is employed to create a microfluidic flow chamber on a chip. It holds a volume of only a few mul and its planar design provides complete architectural freedom. This allows for the reconstruction of even complex flow scenarios (e.g. curvatures, bifurcations and stenosis). Addition of polymer walls to the planar fluidic track enables cell culturing on the chip surface and the investigation of cell-cell adhesion dynamics under flow. We demonstrate the flexibility of the system for application in many areas of microfluidic investigations including blood clotting phenomena under various flow conditions and the investigation of different stages of cell adhesion.

PMID:: 18306189; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

Polymers

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Cited by 1 PubMed Central article

Acoustic driven flow and lattice Boltzmann simulations to study cell adhesion in biofunctionalized mu-fluidic channels with complex geometry. [Biomicrofluidics. 2010]
Acoustic driven flow and lattice Boltzmann simulations to study cell adhesion in biofunctionalized mu-fluidic channels with complex geometry.
Fallah MA, Myles VM, Krüger T, Sritharan K, Wixforth A, Varnik F, Schneider SW, Schneider MF. Biomicrofluidics. 2010 May 19; 4(2). Epub 2010 May 19.

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