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    Am J Hum Genet. 2008 Mar;82(3):744-7. Epub 2008 Feb 21.

    Association of the asporin D14 allele with lumbar-disc degeneration in Asians.

    Song YQ, Cheung KM, Ho DW, Poon SC, Chiba K, Kawaguchi Y, Hirose Y, Alini M, Grad S, Yee AF, Leong JC, Luk KD, Yip SP, Karppinen J, Cheah KS, Sham P, Ikegawa S, Chan D.

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    Department of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong, China.

    Abstract

    Lumbar-disc degeneration (LDD) is a polygenic disease. Susceptibility genes reported so far are mainly extracellular matrix proteins. D14 allele of asporin (ASPN) is associated with osteoarthritis (OA). Candidate-gene association studies showed that the D14 allele is also significantly associated with LDD in Chinese and Japanese individuals. Meta-analysis showed that individuals harboring a D14 allele had higher risk with a summary odds ratio of 1.70 (p = 0.000013). ASPN expression in vertebral discs increased with age and degeneration. Our results indicate ASPN is a LDD gene in Asians, and common risk factors may be considered for OA and LDD.

    PMID:
    18304494
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2427233
    Free PMC Article

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