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    Genome Biol. 2008;9(2):208. Epub 2008 Feb 19.

    Intron mis-splicing: no alternative?

    Roy SW, Irimia M.

    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20814, USA. scottwroy@gmail.com

    A recent report reveals widespread mis-splicing of RNA transcripts in eukaryotes, with mis-spliced RNA destroyed by nonsense-mediated mRNA decay. This striking inefficiency deepens the mystery of the proliferation and persistence of introns.

    PMID: 18304372 [PubMed - indexed for MEDLINE]

    PMCID: PMC2374719

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