Intron mis-splicing: no alternative? [Genome Biol. 2008]

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1: Genome Biol. 2008;9(2):208. Epub 2008 Feb 19. Links

Intron mis-splicing: no alternative?

Roy SW, Irimia M.

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20814, USA. scottwroy@gmail.com

A recent report reveals widespread mis-splicing of RNA transcripts in eukaryotes, with mis-spliced RNA destroyed by nonsense-mediated mRNA decay. This striking inefficiency deepens the mystery of the proliferation and persistence of introns.

PMID: 18304372 [PubMed - indexed for MEDLINE]

PMCID: PMC2374719

ReviewMessenger RNA surveillance and the evolutionary proliferation of introns.
Mol Biol Evol. 2003 Apr; 20(4):563-71. Epub 2003 Mar 5.

[Mol Biol Evol. 2003]
Translational control of intron splicing in eukaryotes.
Nature. 2008 Jan 17; 451(7176):359-62.

[Nature. 2008]
ReviewNonsense-mediated mRNA decay.
Biochem Soc Trans. 2008 Jun; 36(Pt 3):514-6.

[Biochem Soc Trans. 2008]
ReviewThe coupling of alternative splicing and nonsense-mediated mRNA decay.
Adv Exp Med Biol. 2007; 623:190-211.

[Adv Exp Med Biol. 2007]
ReviewCoevolution of genomic intron number and splice sites.
Trends Genet. 2007 Jul; 23(7):321-5. Epub 2007 Apr 18.

[Trends Genet. 2007]
» See reviews... | » See all...

Cited by 2 PubMed Central articles

Evolutionary convergence on highly-conserved 3' intron structures in intron-poor eukaryotes and insights into the ancestral eukaryotic genome.
Irimia M, Roy SW. PLoS Genet. 2008 Aug 8; 4(8):e1000148. Epub 2008 Aug 8.

[PLoS Genet. 2008]
Analysis of sequence variability in the macronuclear DNA of Paramecium tetraurelia: a somatic view of the germline.
Duret L, Cohen J, Jubin C, Dessen P, Goût JF, Mousset S, Aury JM, Jaillon O, Noël B, Arnaiz O, et al. Genome Res. 2008 Apr; 18(4):585-96. Epub 2008 Feb 6.

[Genome Res. 2008]

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