Crit Rev Eukaryot Gene Expr. 2008;18(2):163-72.

Vitamin D control of gene expression: temporal and spatial parameters for organization of the regulatory machinery.

Montecino M, Stein GS, Stein JL, Lian JB, van Wijnen AJ, Carvallo L, Marcellini S, Cruzat F, Arriagada G.

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Laboratory of Cellular and Molecular Biology, Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, University of Concepcion, Casilla 160-C, Concepcion, Chile. mmonteci@udec.cl

Abstract

Vitamin D is a principal modulator of skeletal gene expression, thus necessitating an understanding of interfaces between the activity of this steroid hormone and regulatory cascades that are functionally linked to the regulation of skeletal genes. Physiologic responsiveness requires combinatorial control, whereas co-regulatory proteins determine the specificity of biologic responsiveness to physiologic cues. It is becoming increasingly evident that regulatory complexes containing the vitamin D receptor are dynamic rather than static. Temporal and spatial modifications in the composition of these complexes provide a mechanism for integrating regulatory signals to support positive or negative control through synergism and antagonism. Compartmentalization of components of vitamin D control in nuclear microenvironments supports the integration of regulatory activities, perhaps by establishing thresholds for protein activity in time frames that are consistent with the execution of regulatory signaling.

PMID:: 18304030; [PubMed - indexed for MEDLINE]

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Review An architectural perspective of vitamin D responsiveness. [Arch Biochem Biophys. 2007]
Review An architectural perspective of vitamin D responsiveness.
Montecino M, Stein GS, Cruzat F, Marcellini S, Stein JL, Lian JB, van Wijnen AJ, Arriagada G. Arch Biochem Biophys. 2007 Apr 15; 460(2):293-9. Epub 2007 Jan 8.
Review The dynamic organization of gene-regulatory machinery in nuclear microenvironments. [EMBO Rep. 2005]
Review The dynamic organization of gene-regulatory machinery in nuclear microenvironments.
Zaidi SK, Young DW, Choi JY, Pratap J, Javed A, Montecino M, Stein JL, van Wijnen AJ, Lian JB, Stein GS. EMBO Rep. 2005 Feb; 6(2):128-33.
Review Intranuclear trafficking of transcription factors: Requirements for vitamin D-mediated biological control of gene expression. [J Cell Biochem. 2003]
Review Intranuclear trafficking of transcription factors: Requirements for vitamin D-mediated biological control of gene expression.
Stein GS, Lian JB, Stein JL, Wijnen AJ, Montecino M, Javed A, Pratap J, Choi J, Zaidi SK, Gutierrez S, et al. J Cell Biochem. 2003 Feb 1; 88(2):340-55.
Review Nuclear microenvironments support physiological control of gene expression. [Chromosome Res. 2003]
Review Nuclear microenvironments support physiological control of gene expression.
Stein GS, Lian JB, Montecino M, Stein JL, van Wijnen AJ, Javed A, Pratap J, Choi J, Zaidi SK, Gutierrez S, et al. Chromosome Res. 2003; 11(5):527-36.
Review The temporal and spatial subnuclear organization of skeletal gene regulatory machinery: integrating multiple levels of transcriptional control. [Calcif Tissue Int. 2003]
Review The temporal and spatial subnuclear organization of skeletal gene regulatory machinery: integrating multiple levels of transcriptional control.
Lian JB, Stein GS. Calcif Tissue Int. 2003 Jun; 72(6):631-7.

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Cited by 1 PubMed Central article

Organization, integration, and assembly of genetic and epigenetic regulatory machinery in nuclear microenvironments: implications for biological control in cancer. [Ann N Y Acad Sci. 2009]
Organization, integration, and assembly of genetic and epigenetic regulatory machinery in nuclear microenvironments: implications for biological control in cancer.
Stein GS, Zaidi SK, Stein JL, Lian JB, van Wijnen AJ, Montecino M, Young DW, Javed A, Pratap J, Choi JY, et al. Ann N Y Acad Sci. 2009 Feb; 1155:4-14.

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