[Effects of Lycium barbarum on the behavior, body weight and TNF-alpha level of rat treated with binding]

Department of Environmental Health, Ningxia Medical College, Yinchuan 750004, China. lihh31@sina.com

OBJECTIVE: To explore the effects of Lycium barbarum (L) on the behavior and body weight and TNF-alpha level of rat treated with binding. METHODS: Rats were randomly divided into 6 groups: control group,binding group, 2.5% L group, 5.0% L group, 2.5% L plus binding group, 5.0% L plus binding group. Lycium barbarums were pressed into juice, then rats were fed with the dranking water contening juice. Rats were bound to restrict for 21 days. RESULTS: (1) The increases of serum-cortisol level and the decreases of body weight and the increases of TNF-alpha level of rats of binding group in comparision with control groups (P < 0.05) (2) Rats body weight gain, movement and TNF-alpha level in both of 2.5% L plus binding group and 5.0% L plus binding group were more higher than those in binding group (P < 0.05). Serum-cortisol level of these two groups were more lower and had statistical significance in comparison with those of binding groups (P < 0.05). CONCLUSION: Binding could suppress body weight gain and markedly reduce the activity and TNF-alpha level of rat. Lycium barbarum could be a good adjustment on the behavior, body weight and TNF-alpha.

PMID: 18303642 [PubMed - in process]