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Clin Obstet Gynecol. 2008 Mar;51(1):84-95. doi: 10.1097/GRF.0b013e318161719c.

Genetics of pregnancy loss.

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  • 1Departments of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Utah, Salt Lake City, Utah, USA.


Pregnancy loss is a common problem in reproductive-aged women. Although most cases of pregnancy loss are sporadic, some couples experience recurrent pregnancy loss, a challenging clinical dilemma. A variety of possible etiologies have been described for both sporadic and recurrent pregnancy loss. This review focuses on the genetic abnormalities that may contribute to this clinical problem and delineates strategies for genetic evaluation and clinical management in subsequent pregnancies.

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