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AIDS. 2008 Feb 19;22(4):540-1. doi: 10.1097/QAD.0b013e3282f37812.

HLA-DRB1*01 associated with cutaneous hypersensitivity induced by nevirapine and efavirenz.

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  • 1INSERM, U563, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France.


HLA typing, demographic and immunological risk factors for nevirapine and efavirenz reactions were studied in a French cohort of HIV patients. Cases with isolated rash were significantly associated with HLA-DRB101 allele. No liver toxicity was observed and no association was detected with the percentage of CD4 T-cells. This study suggests that HLA-DRB101 allele plays an important role in susceptibility to cutaneous reactions associated with nevirapine and efavirenz in HIV patients.

[PubMed - indexed for MEDLINE]
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