Isr Med Assoc J. 2008 Jan;10(1):79-82.

Chronic fatigue syndrome: characteristics and possible causes for its pathogenesis.

Bassi N, Amital D, Amital H, Doria A, Shoenfeld Y.

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Department of Rheumatology, University of Padova, Padova, Italy.

Abstract

Chronic fatigue syndrome is a heterogeneous disorder with unknown pathogenesis and etiology, characterized by disabling fatigue, difficulty in concentration and memory, and concomitant skeletal and muscular pain. Several mechanisms have been suggested to play a role in CFS, such as excessive oxidative stress following exertion, immune imbalance characterized by decreased natural killer cell and macrophage activity, immunoglobulin G subclass deficiencies (IgG1, IgG3) and decreased serum concentrations of complement component. Autoantibodies were also suggested as a possible factor in the pathogenesis of CFS. Recent studies indicate that anti-serotonin, anti-microtubule-associated protein 2 and anti-muscarinic cholinergic receptor 1 may play a role in the pathogenesis of CFS. It has been demonstrated that impairment in vasoactive neuropeptide metabolism may explain the symptoms of CFS.

PMID:: 18300582; [PubMed - indexed for MEDLINE]

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