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J Natl Med Assoc. 2008 Feb;100(2):256-8.

A 46XX disorder of sex development with a prostate gland and increased level of prostate-specific antigen.

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  • 1Department of Pediatric Endocrinology, Gazi University Medical School, Ankara, Turkey.


A 5-year-old child with precocious puberty and complete masculinization of the genitalia was diagnosed to have 21-hydroxylase deficiency. The patient was also found to have a prostate gland and increased prostate-specific antigen. The presence of a prostate and its relation to prostate-specific antigen and prostate adenocarcinoma are discussed in the light of the relevant literature.

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