T-cell-targeted signaling inhibitors

Int Rev Immunol. 2008 Jan-Apr;27(1-2):19-41. doi: 10.1080/08830180701798976.

Abstract

Recent advances in our understanding of the mechanisms of T-cell activation, migration to inflammatory sites, and pathologic disease processes triggered the development of a wide variety of T-cell-targeted signaling inhibitors, which have different targets and modes of action. Depending on the distribution and the role of targets in disease processes, T-cell inhibitors exhibit different levels of efficacy and potential side effects. This review outlines target molecules to which T-cell inhibitors have been developed, their efficacy, and potential safety concerns of T-cell inhibitors.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcineurin / metabolism
  • Calcineurin Inhibitors
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Humans
  • Janus Kinase 3 / antagonists & inhibitors
  • Janus Kinase 3 / metabolism
  • Lymphocyte Activation / drug effects
  • Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / antagonists & inhibitors
  • Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / metabolism
  • Lysophospholipids / antagonists & inhibitors
  • Lysophospholipids / metabolism
  • NFATC Transcription Factors / antagonists & inhibitors
  • NFATC Transcription Factors / metabolism
  • Phosphatidylinositol 3-Kinases / metabolism
  • Phosphoinositide-3 Kinase Inhibitors
  • Protein-Tyrosine Kinases / antagonists & inhibitors
  • Protein-Tyrosine Kinases / metabolism
  • Receptors, Antigen, T-Cell / metabolism
  • Signal Transduction / drug effects
  • Sphingosine / analogs & derivatives
  • Sphingosine / antagonists & inhibitors
  • Sphingosine / metabolism
  • T-Lymphocyte Subsets / drug effects*
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocyte Subsets / metabolism*

Substances

  • Calcineurin Inhibitors
  • Enzyme Inhibitors
  • Lysophospholipids
  • NFATC Transcription Factors
  • Phosphoinositide-3 Kinase Inhibitors
  • Receptors, Antigen, T-Cell
  • sphingosine 1-phosphate
  • Protein-Tyrosine Kinases
  • Janus Kinase 3
  • Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
  • Calcineurin
  • Sphingosine