Integrating sensitive quantification of hepatic metabolic functions by capillary electrophoresis with laser-induced fluorescence detection

Analyst. 2008 Mar;133(3):326-30. doi: 10.1039/b716420c. Epub 2008 Feb 5.

Abstract

We report the establishment of capillary electrophoresis with laser-induced fluorescence (CE-LIF) detection as a common analytical platform for sensitive quantification of both phase I and II metabolism in various hepatic in vitro models.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Culture Techniques
  • Electrophoresis, Capillary / methods*
  • Fluorescent Dyes
  • Humans
  • Lasers
  • Liver / chemistry
  • Liver / metabolism*
  • Spectrometry, Fluorescence / methods*

Substances

  • Fluorescent Dyes