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Semin Cell Dev Biol. 2008 Jun;19(3):234-44. doi: 10.1016/j.semcdb.2008.01.002. Epub 2008 Jan 20.

The PIX-GIT complex: a G protein signaling cassette in control of cell shape.

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  • 1GI Cell Biology Laboratory, The Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.


Arf and Rho GTP-binding proteins coordinately regulate membrane dynamics and cytoskeletal rearrangements. The Cdc42/Rac guanine nucleotide exchange factor PIX and the Arf GTPase-activating protein GIT form a stable complex in cells. The PIX-GIT complex functions to integrate signaling among Arf, Cdc42, and Rac proteins in response to cues emanating from integrins, heterotrimeric G proteins, receptor tyrosine kinases, and cell-cell interactions. A concept that emerges from the literature is that the PIX-GIT complex serves as a cassette to elicit changes in cell shape essential for polarized cell responses in a wide range of biological contexts.

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