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Biochemistry (Mosc). 2008 Feb;73(2):130-8.

Light damaging action of all-trans-retinal and its derivatives on rhodopsin molecules in the photoreceptor membrane.

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  • 1Emanuel' Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia. marina.loguinova@mail.ru

Abstract

We have reproduced the model system containing A2-rhodopsin, NR-PE, A2-PE, and ATR-dimer-PE in order to study photosensitized damage of rhodopsin within photoreceptor membranes of rod outer segments. We have demonstrated that irradiation of such a system with visible light (400-700 nm) distorts the most important functional property of native visual pigment--its ability to regenerate after addition of 11-cis-retinal in the dark. We have also shown that all-trans-retinal bound to membrane phospholipids and rhodopsin has less photosensitizing activity that free all-trans-retinal.

PMID:
18298368
[PubMed - indexed for MEDLINE]
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