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    J Affect Disord. 1991 Mar;21(3):151-62.

    Predictors of antidepressant treatment outcome in melancholia: psychosocial, clinical and biological indicators.

    Vallejo J, Gasto C, Catalan R, Bulbena A, Menchon JM.

    Source

    Department of Psychiatry, Hospital of Bellvitge School of Medicine, Barcelona, Spain.

    Abstract

    Predictive variables of response to imipramine and to phenelzine at 6 weeks and 6 months were studied in 116 patients suffering from major depression with melancholia (DSM-III). Several sociodemographic, clinical, and biological variables were studied. For imipramine-treated patients, high social support predicted a better response at 6 weeks, while development of hypomania during follow-up was associated with a better response at 6 weeks; absence of life events during the 6-month follow-up and initial non-suppression of dexamethasone predicted a better outcome at 6 months. For phenelzine-treated patients, development of hypomania during follow-up was associated with a better outcome at 6 months and absence of life events prior to the onset of the episode was associated with a worse outcome at 6 months.

    PMID:
    1829739
    [PubMed - indexed for MEDLINE]

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