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Biochim Biophys Acta. 2008 Jul-Aug;1778(7-8):1545-75. doi: 10.1016/j.bbamem.2008.01.015. Epub 2008 Feb 7.

Protein modulation of lipids, and vice-versa, in membranes.

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  • 1Max-Planck-Institut für biophysikalische Chemie, Abt. Spektroskopie, Göttingen, Germany. dmarsh@gwdg.de


This review describes: (i) perturbations of the membrane lipids that are induced by integral membrane proteins, and reciprocally, (ii) the effects that the lipids may have on the function of membrane-associated proteins. Topics of the first category that are covered include: stoichiometry and selectivity of the first shell of lipids associated at the intramembranous perimeter of transmembrane proteins; the chain configuration and exchange rates of the first-shell lipids; the effects of transmembrane peptides on transbilayer movement of lipids (flip-flop); the effects of membrane proteins on lipid polymorphism and formation of non-lamellar phases; and the effects of hydrophobic mismatch on lipid chain configuration, phase stability and selectivity of lipid-protein association. Topics of the second category are: the influence of lipid selectivity on conformational changes in the protein; the effects of elastic fluctuations of the lipid bilayer on protein insertion and orientation in membranes; the effects of hydrophobic matching on intramembrane protein-protein association; and the effects of intrinsic lipid curvature on membrane integration, oligomer formation and activity of membrane proteins.

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