J Subst Abuse Treat. 2008 Oct;35(3):304-11. Epub 2008 Feb 21.

Adverse events in an integrated trauma-focused intervention for women in community substance abuse treatment.

Killeen T, Hien D, Campbell A, Brown C, Hansen C, Jiang H, Kristman-Valente A, Neuenfeldt C, Rocz-de la Luz N, Sampson R, Suarez-Morales L, Wells E, Brigham G, Nunes E.

Source

Clinical Neuroscience, Medical University of South Carolina, Charleston, SC 29451, USA. killeent@musc.edu

Abstract

A substantial number of women who enter substance abuse treatment have a history of trauma and meet criteria for posttraumatic stress disorder (PTSD). Fear regarding the extent to which PTSD treatment can evoke negative consequences remains a research question. This study explored adverse events related to the implementation of an integrated treatment for women with trauma and substance use disorder (Seeking Safety) compared with a nontrauma-focused intervention (Women's Health Education). Three hundred fifty-three women enrolled in community substance abuse treatment were randomized to 1 of the 2 study groups and monitored weekly for adverse events. There were no differences between the two intervention groups in the number of women reporting study-related adverse events (28 [9.6%] for the Seeking Safety group and 21[7.2%] for the Women's Health Education group). Implementing PTSD treatment in substance abuse treatment programs appears to be safe, with minimal impact on intervention-related adverse psychiatric and substance abuse symptoms. More research is needed on the efficacy of such interventions to improve outcomes of PTSD and substance use.

PMID:: 18294804; [PubMed - indexed for MEDLINE]

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Clinical Trials Network (CTN) Data Share: Clinical Trials Network: Women's Treatment for Trauma and Substance Use Disorders - Neuroscience Information Framework

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