Praxis (Bern 1994). 2007 Aug 29;96(35):1309-14.

[Floppy baby with macrocytic anemia and vegan mother].

[Article in German]

Schlapbach LJ, Schütz B, Nuoffer JM, Brekenfeld C, Müller G, Fluri S.

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Medizinische Universitäts-Kinderklinik, Inselspital, Bern. luregn.schlapbach@insel.ch

Abstract

We report the case of a 7 month-old girl that presented with acute anemia, generalized muscular hypotonia and failure to thrive. Laboratory evaluation revealed cobalamin deficiency, due to a vegan diet of the mother. The clinical triad of an acquired floppy baby syndrome with megaloblastic anemia and failure to thrive is pathognomic for infantile cobalamin deficiency. Neurological abnormalities are often irreversible and may be associated with delayed myelinization in the MRI. A normal cobalamin level in maternal serum and absence of anemia do not exclude subclinical deficiency. If cobalamin deficiency is suspected, e.g. in pregnant women on vegan diet, urinary methylmalonic acid excretion and plasma homocysteine levels should be determined and cobalamin substitution should be started at an early stage to avoid potentially irreversible damage of the fetus.

PMID:: 18293883; [PubMed - indexed for MEDLINE]

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Nutritional vitamin B12 deficiency in a breast-fed infant of a vegan-diet mother. [Clin Pediatr (Phila). 1986]
Nutritional vitamin B12 deficiency in a breast-fed infant of a vegan-diet mother.
Sklar R. Clin Pediatr (Phila). 1986 Apr; 25(4):219-21.
[Metabolic complications and neurologic manifestations of vitamin B12 deficiency in children of vegetarian mothers]. [Cas Lek Cesk. 2001]
[Metabolic complications and neurologic manifestations of vitamin B12 deficiency in children of vegetarian mothers].
Smolka V, Bekárek V, Hlídková E, Bucil J, Mayerová D, Skopková Z, Adam T, Hrubá E, Kozich V, Buriánková L, et al. Cas Lek Cesk. 2001 Nov 22; 140(23):732-5.
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Monfort-Gouraud M, Bongiorno A, Le Gall MA, Badoual J. Ann Pediatr (Paris). 1993 Jan; 40(1):28-31.
Review Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms. [Nutr Rev. 2008]
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