Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Tissue Eng Regen Med. 2008 Jan;2(1):1-13. doi: 10.1002/term.63.

Bone morphogenetic proteins in tissue engineering: the road from the laboratory to the clinic, part I (basic concepts).

Author information

  • 13Bs Research Group, Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal. paulo.bessa@dep.uminho.pt

Abstract

Discovered in 1965, bone morphogenetic proteins (BMPs) are a group of cytokines from the transforming growth factor-beta (TGFbeta) superfamily with significant roles in bone and cartilage formation. BMPs are used as powerful osteoinductive components of diverse tissue-engineering products for the healing of bone. Several BMPs with different physiological roles have been identified in humans. The purpose of this review is to cover the biological function of the main members of BMP family, the latest research on BMPs signalling pathways and advances in the production of recombinant BMPs for tissue engineering purposes.

Copyright (c) 2008 John Wiley & Sons, Ltd.

PMID:
18293427
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for John Wiley & Sons, Inc.
    Loading ...
    Write to the Help Desk