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Sleep Med Rev. 2008 Apr;12(2):95-107. doi: 10.1016/j.smrv.2007.07.010. Epub 2008 Mar 4.

Narcolepsy: immunological aspects.

Author information

  • 1Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. s.overeem@neuro.umcn.nl

Abstract

Narcolepsy with cataplexy is a debilitating sleep disorder with an estimated prevalence of about 0.05%. Narcolepsy is caused by a selective loss of hypocretin (orexin) producing neurons in the perifornical hypothalamus. Based on the very strong association with the HLA subtype DQB1*0602, it is currently hypothesized narcolepsy is caused by an autoimmune-mediated process directed at the hypocretin neurons. So far however, studies focusing on general markers of (auto)immune activation, as well as humoral immunity against the hypocretin system have not yielded consistent results supporting this hypothesis.

PMID:
18291691
[PubMed - indexed for MEDLINE]
PMCID:
PMC2366136
Free PMC Article
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