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Chem Biol. 2008 Feb;15(2):95-6. doi: 10.1016/j.chembiol.2008.02.005.

Toward the pathway of S. aureus WTA biosynthesis.

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  • 1Cellular and Molecular Microbiology Section, Medical Microbiology and Hygiene Department, University of Tübingen, Elfriede-Aulhorn-Strasse 6, 72076 Tübingen, Germany.


Wall teichoic acid (WTA) contributes profoundly to the virulence of Staphylococcus aureus. The successful in vitro reconstitution of poly-ribitolphosphate WTA biosynthesis using recombinant enzymes sheds new light on WTA enzymology and paves the way for developing new antibiotics that target WTA biosynthesis, as discussed in Brown et al. in a recent issue of Chemistry & Biology.

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