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1: J Bone Miner Res. 2007 Dec;22 Suppl 2:V25-7.Click here to read Links

Vitamin D endocrine physiology.

Heaney RP.

Creighton University, Omaha, Nebraska, USA.

Quantitative aspects of vitamin D(3) endocrine physiology are briefly reviewed, together with the supporting evidence. Net calcium absorption of at least 200 mg/d is required to offset typical obligatory losses and thereby to protect the skeleton. The ability of the body to regulate intestinal calcium absorption is optimal at serum 25-hydroxyvitamin D(3) concentrations >80 nM. Vitamin D(3) inputs from all sources required to sustain such a level amount to 3600-4200 IU/d. Daily oral intakes as high as 10,000 IU are safe.

PMID: 18290717 [PubMed - indexed for MEDLINE]

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