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Sci Signal. 2008;1(7):tr1.

Teaching resource. Quantitative models of mammalian cell signaling pathways.

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  • 1Department of Pharmacology and SystemsTherapeutics, Mount Sinai School ofMedicine, New York, NY 10029, USA.


This teaching resource provides lecture notes and slides for a class on mathematical modeling of mammalian signaling pathways. This lecture was part of the course . Cell Signaling Systems: A Course for Graduate Students. and focused on quantitative modeling. The lecture describes how different types of mathematical representations are applied to different signaling systems to provide insight into how a signaling system controls cell behavior. The development of an ordinary differential equation.based model for a bistable switch and the predictions that can be obtained from the model are described. The lecture concludes with a description of how models can be tested experimentally and modified when the details of the models and the resultant predictive behavior are not confirmed by experimentation.

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