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1: Am J Gastroenterol. 2008 Feb;103(2):424-6.Click here to read Links
Comment on:
Am J Gastroenterol. 2008 Feb;103(2):416-23.

Beyond gastric emptying: a "toxic" lesson about gastroparesis.

Pasricha PJ.

The first published controlled trial of intrapyloric botulinum toxin for gastroparesis failed to demonstrate a significant effect of treatment on symptoms, despite an improvement in gastric emptying. In this editorial, I discuss the limitations and implications of this study, with particular emphasis on what the use of botulinum toxin can teach us about the pathophysiology of gastroparesis and other gastrointestinal smooth muscle disorders.

PMID: 18289204 [PubMed - indexed for MEDLINE]