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Arch Virol. 2008;153(4):749-54. doi: 10.1007/s00705-008-0057-2. Epub 2008 Feb 21.

HN protein of Newcastle disease virus causes apoptosis in chicken embryo fibroblast cells.

Author information

  • 1Division of Animal Biotechnology, Indian Veterinary Research Institute, Izatnagar, 243122, India.

Erratum in

  • Arch Virol. 2014 Aug;159(8):2205. Kumar, G B Aruna [corrected to Gangaplara, Arunakumar].


Newcastle disease virus (NDV), an avian paramyxovirus, induces apoptosis in chicken embryo fibroblast (CEF) cells. In the present investigation, the ability of haemagglutinin-neuraminidase (HN) protein of NDV to cause apoptosis in CEF cells was examined. The results revealed that cells expressing the HN protein demonstrated decreased DNA content, phosphatidylserine exposure and increased cytoplasmic vacuolation. Up-regulation of caspase-1, -9, -8, -3, loss of mitochondrial transmembrane potential and an increase in oxidative stress were also observed in cells expressing the HN protein. Based on the above results it can be concluded that HN protein of NDV causes apoptosis in CEF cells.

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