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Nature. 2008 Feb 21;451(7181):943-8. doi: 10.1038/nature06801.

The developmental genetics of congenital heart disease.

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  • 1Gladstone Institute of Cardiovascular Disease, and Department of Pediatrics, University of California San Francisco, 1650 Owens Street, San Francisco, California 94158, USA.


Congenital heart disease is the leading cause of infant morbidity in the Western world, but only in the past ten years has its aetiology been understood. Recent studies have uncovered the genetic basis for some common forms of the disease and provide new insight into how the heart develops and how dysregulation of heart development leads to disease.

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