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J Clin Microbiol. 2008 Apr;46(4):1530-3. doi: 10.1128/JCM.01964-07. Epub 2008 Feb 20.

Increased sporulation rate of epidemic Clostridium difficile Type 027/NAP1.

Author information

  • 1Swedish Institute for Infectious Disease Control, Department of Bacteriology, SE-171 82, Solna, Sweden. Thomas.Akerlund@smi.ki.se

Abstract

Clostridium difficile PCR ribotype 027 comprised 0.2% of a collection of Swedish isolates in 1997-2001 (3 of 1,325 isolates). These isolates had lower moxifloxacin MICs than the epidemic type 027 isolates, but they had the same tcdC sequence and toxin yield. Type 027 produced 3- to 13-fold more toxin than did major Swedish types. One epidemic strain (027/NAP1a) sporulated more than did other type 027 isolates, a feature that should contribute to its survival and spread.

PMID:
18287318
[PubMed - indexed for MEDLINE]
PMCID:
PMC2292905
Free PMC Article

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