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J Cell Physiol. 2008 Jun;215(3):575-7. doi: 10.1002/jcp.21397.

Bag3 gene expression is regulated by heat shock factor 1.

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  • 1Department of Pharmaceutical Sciences (DiFarma), University of Salerno, Salerno, Italy.


BAG3 protein, a member of the BAG co-chaperones family, sustains cell survival, through its interaction with the heat shock protein (HSP) 70, in a variety of normal and neoplastic cell types. bag3 gene expression is induced by stressful stimuli. Here we report for the first time that two of the three putative heat shock-responsive elements (HSEs) in bag3 promoter interact with the heat shock factor (HSF) 1 in vitro and in vivo. Furthermore, downmodulation of HSF1 protein levels by specific small interfering (si) RNAs results in reducing BAG3 protein levels, indicating that the transcription factor plays a major role in bag3 gene expression. Because of the anti-apoptotic role of BAG3 protein, these results disclose a previously unrecognized pathway, through which HSF1 maintains cell survival.

(c) 2008 Wiley-Liss, Inc.

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