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Head Neck. 2008 Jun;30(6):737-42. doi: 10.1002/hed.20769.

N2-N3 neck nodal control without planned neck dissection for clinical/radiologic complete responders-results of Trans Tasman Radiation Oncology Group Study 98.02.

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  • 1Division of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia. june.corry@petermac.org

Abstract

BACKGROUND:

The aim of this study was to determine the incidence of isolated nodal failure in patients with N2/3 disease who achieved a complete clinical and radiological response (CR) at 12 weeks postchemoradiation, when no planned neck dissection was performed.

METHODS:

We analyzed the nodal response and subsequent neck control of 102 patients with initial N2/3 disease treated on the Trans Tasman Radiation Oncology Group 98.02 study.

RESULTS:

With a median 4.3 years follow-up, the patterns of first failure in the CR patients were local 4%, local and nodal 2%, distant 28%, and locoregional plus distant (within 1 month) 6%. There were no patients who had only neck failure.

CONCLUSION:

Patients in this trial with N2/3 disease who obtained a clinical and radiological complete response to chemoradiation had a zero incidence of isolated neck failure without a planned neck dissection. The continued use of planned neck dissections in this patient subset cannot be justified.

PMID:
18286488
[PubMed - indexed for MEDLINE]
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