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J Surg Oncol. 2008 Mar 15;97(4):330-9. doi: 10.1002/jso.20972.

Diagnosis and management of pleomorphic sarcomas (so-called "MFH") in adults.

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  • 1Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.


The existence of "malignant fibrous histiocytoma" ("MFH") as a distinct entity is controversial. Previously accepted as the most common sarcoma affecting adults, it is now known to comprise a heterogeneous group of tumors without a specific known line of differentiation. Reclassification of many tumors in this group afforded better prognostication, but traditional treatments still apply. Pleomorphic soft tissue tumors for which a line of differentiation is debatable are presently categorized as undifferentiated pleomorphic sarcoma.

(c) 2008 Wiley-Liss, Inc.

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