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J Surg Oncol. 2008 Mar 15;97(4):340-9. doi: 10.1002/jso.20971.

Malignant Peripheral Nerve Sheath Tumor: molecular pathogenesis and current management considerations.

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  • 1Department of Surgery, Division of Surgical Oncology and Endocrine Surgery, University of Florida, Gainesville, Florida, USA.


Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are rare tumors that often occur in patients with neurofibromatosis 1. Surgical resection represents the mainstay of treatment. Radiation and chemotherapy have a role in selected patients with MPNST. Accurate pathologic diagnosis remains a challenge in many cases of MPNST. There are many recent advances in the understanding of the molecular pathogenesis of MPNST which represent the best opportunities to develop new strategies for management of patients with MPNST.

(c) 2008 Wiley-Liss, Inc.

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