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Cancer Causes Control. 2008 Aug;19(6):549-58. doi: 10.1007/s10552-008-9123-z. Epub 2008 Feb 20.

Personal use of hair dyes and risk of bladder cancer: a meta-analysis of epidemiologic data.

Author information

  • 1Exponent, 149 Commonwealth Drive, Menlo Park, CA 94025, USA. mkelsh@exponent.com

Abstract

OBJECTIVE:

We compared, updated, and expanded the analyses of two previous meta-analyses of personal hair dye exposure and bladder cancer, and briefly discussed the biological plausibility of a systemic hazard to human health from exposure to para-phenylenediamine (PPD), a key chemical in hair dyes.

METHODS:

The meta-analysis included 11 case-control studies and one cohort study. We evaluated heterogeneity across studies and conducted sensitivity and influence analyses.

RESULTS:

No association was found between any personal use of hair dye and bladder cancer among women (meta-relative risk [mRR] = 1.01, 95% CI: 0.89-1.14), men (mRR = 0.82, 95% CI: 0.60-1.14), or both sexes combined (mRR = 0.97, 95% CI: 0.87-1.08). No statistically significant mRRs were found among the studies that reported data for permanent hair dye use (mRR = 1.06, 95% CI: 0.89-1.27), duration of any hair dye use (mRR = 1.00, 95% CI: 0.85-1.19), duration of permanent hair dye use (mRR = 1.31 95% CI 0.78-2.19), lifetime applications of any hair dye use (mRR = 1.12 (95% CI: 0.72-1.72) or permanent hair dye use (mRR = 1.59, 95% CI 0.69-3.64), or dark color hair dye use (mRR = 0.94, 95% CI: 0.74-1.19).

CONCLUSION:

The results of this meta-analysis of epidemiologic studies do not indicate a causal association between personal hair dye use and bladder cancer.

PMID:
18286379
[PubMed - indexed for MEDLINE]
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